SIRT1 and tumor resistance
نویسنده
چکیده
SIRT1 is a NAD+ (nicotinamide adenine dinucleotide) dependent histone deacetylase. Growing evidences suggestes that SIRT1 plays the part of metabolic sensor in regulating the level of acetylation in cell proliferation and other aspects of tumor development. The expression of SIRT1 is related to multiple pathways of resistance. In this review, we have summarizes the recent progress of SIRT1, and provides the overview of the correlation with cancer drug resistance by targeting SIRT1.
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